Synthesis of Novel Multifunctional bora-Ibuprofen Derivatives
نویسندگان
چکیده
A unique class of β-boron-functionalized non-steroidal anti-inflammatory compound (pinB-NSAID) was previously synthesized via copper-catalyzed 1,2-difunctionalization the respective vinyl arene with CO2 and B2pin2 reagents. Here, pinacolylboron-functionalized ibuprofen (pinB-ibuprofen) used as a model substrate to develop conditions for pinacol deprotection subsequent boron functionalization. Initial pinacol-boronic ester achieved by transesterification diethanolamine (DEA) from boralactonate organic salt. The resulting DEA boronate adopts spirocyclic structure rather than diazaborocane–DABO structure. acid-mediated hydrolysis transesterification/transamination provided diverse scope new boron-containing derivatives.
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ژورنال
عنوان ژورنال: Inorganics (Basel)
سال: 2023
ISSN: ['2304-6740']
DOI: https://doi.org/10.3390/inorganics11020070